My lab has extensively worked on understanding the regulation of key metabolic pathways of crops like tea, stevia, rice and horsegram. We have developed low caffeine Kangra jat tea through silencing of caffeine synthase gene. We have proved that three genes CsF3H, CsDFR and CsANR from tea play important role in yield enhancement and stress tolerance. Such genes are potential candidate for commercial production of high value antioxidant particularly catechins. We have developed seed less/ low seeded fruits through PTGS of flavonol synthase mRNA. We have provided first evidence of epigenetic regulation of flavonoid biosynthesis and antioxidant pathway during salinity stress. We have unraveled the molecular regulation of steviol glycosides in stevia and achieved enhanced GAs production through silencing of SGs pathway genes. The transformation of SGs pathway genes in alternate plants has been proved to be a commercial source for SGs production. We have elucidated the molecular regulation mechanism of glyoxalase pathway and its role in providing stress tolerance to crop plants. We have characterized first time transcriptome, DNA methylation polymorphism, protein-protein interactome and small RNAs for a drought sensitive and a drought responsive horsegram.
Considering the national shift, our recent work is mainly focused on translation research and development of commercial technologies. We have developed edible coatings from waste biomass and demonstrated their use in shelf life enhancement of fruits and vegetables. We have found that cold plasma and ultrasonication are useful technologies for the retention of quality and antioxidants potential of agri-biomass derived value added products. We have identified an ethanol tolerant bacterium Acetobacter pasteurianus SKYAA25 for acetic acid production from apple pomace. We have also developed an efficient and economic process for the production of cellulose by a bacterium Acetobacter pasteurianus RSV-4. Yet another technology on processing-independent extracellular production of high purity C-phycocyanin from Spirulina platensis has been developed. A direct process has been developed for recovery of nano-silica and lignin from paddy straw agro-waste. We have developed microbes/ enzymes based process technologies for the production of rare sugars, tagatose, ribose and talose. Efficacy of such processes have further been enhanced and made sustainable through immobilization techniques. Also, xylanase of Acinetobacter pitti MASK-25 has been used for the sustainable production of novel prebiotics from agro biomass. We have already transferred four technologies, filed/granted 17 patents, published 3 books, 20 book chapters and 200 research papers with >23000 citations; h-index of 52. We have already completed 25 research projects funded by DBT, DST, CSIR, DRDO, BIRAC, etc. We have completed 2 Indo-UK projects under innovate fund and pursuing BRICS project on biomass valorization.
Biography:
Sudesh Kumar Yadav
Center of Innovative and Applied Bioprocessing
My lab has extensively worked on understanding the regulation of key metabolic pathways of crops like tea, stevia, rice and horsegram. We have developed low caffeine Kangra jat tea through silencing of caffeine synthase gene. We have proved that three genes CsF3H, CsDFR and CsANR from tea play important role in yield enhancement and stress tolerance. Such genes are potential candidate for commercial production of high value antioxidant particularly catechins. We have developed seed less/ low seeded fruits through PTGS of flavonol synthase mRNA. We have provided first evidence of epigenetic regulation of flavonoid biosynthesis and antioxidant pathway during salinity stress. We have unraveled the molecular regulation of steviol glycosides in stevia and achieved enhanced GAs production through silencing of SGs pathway genes. The transformation of SGs pathway genes in alternate plants has been proved to be a commercial source for SGs production. We have elucidated the molecular regulation mechanism of glyoxalase pathway and its role in providing stress tolerance to crop plants. We have characterized first time transcriptome, DNA methylation polymorphism, protein-protein interactome and small RNAs for a drought sensitive and a drought responsive horsegram.
Considering the national shift, our recent work is mainly focused on translation research and development of commercial technologies. We have developed edible coatings from waste biomass and demonstrated their use in shelf life enhancement of fruits and vegetables. We have found that cold plasma and ultrasonication are useful technologies for the retention of quality and antioxidants potential of agri-biomass derived value added products. We have identified an ethanol tolerant bacterium Acetobacter pasteurianus SKYAA25 for acetic acid production from apple pomace. We have also developed an efficient and economic process for the production of cellulose by a bacterium Acetobacter pasteurianus RSV-4. Yet another technology on processing-independent extracellular production of high purity C-phycocyanin from Spirulina platensis has been developed. A direct process has been developed for recovery of nano-silica and lignin from paddy straw agro-waste. We have developed microbes/ enzymes based process technologies for the production of rare sugars, tagatose, ribose and talose. Efficacy of such processes have further been enhanced and made sustainable through immobilization techniques. Also, xylanase of Acinetobacter pitti MASK-25 has been used for the sustainable production of novel prebiotics from agro biomass. We have already transferred four technologies, filed/granted 17 patents, published 3 books, 20 book chapters and 200 research papers with >23000 citations; h-index of 52. We have already completed 25 research projects funded by DBT, DST, CSIR, DRDO, BIRAC, etc. We have completed 2 Indo-UK projects under innovate fund and pursuing BRICS project on biomass valorization.